Andrew Card was elected to the Massachusetts House of Representatives in 1975 and served until 1983. He went on to serve in President Reagan's administration in various positions, including deputy assistant to the president and director of intergovernmental affairs.
From 1988 to 1992, Card served in President George H. W. Bush's administration as assistant to the president and deputy chief of staff.
From 1992 until 1993, Card served as the 11th U.S. secretary of transportation. In August 1992, at the request of President Bush, Card coordinated the administration's disaster relief efforts in the wake of Hurricane Andrew. Later that year, Card directed President Bush's office during the transition from the Bush administration to the Clinton administration. From 1993 to 1998, Card was president and chief executive officer of the American Automobile Manufacturers Association.
On November 26, 2000, Card was appointed chief of staff to George W. Bush. Card's last day as chief of staff was April 14, 2006, making him the second-longest-serving White House chief of staff.
From 2011 to 2014, Card served as acting dean at the Bush School of Government and Public Service at Texas A&M University and as executive director in the Office of the Provost.
Card graduated from the University of South Carolina with a B.S. in engineering. He attended the United States Merchant Marine Academy and the John F. Kennedy School of Government at Harvard University.